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pentobarbital will reduce the extent or effect of tacrolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will minimize the level or outcome of darifenacin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the extent or impact of diazepam by